The wavelength of CO2 laser is 10.6μm, which can be fully absorbed by human biology tissue. The sealed-off fractional CO2 laser, whose output laser-light will be transferred by articulated arm, which has better sense of direction and higher energy density.

The CO2 laser operates in the invisible infrared waveband, and an aiming beam is required to see where the treatment beam will impact tissue more recently from a visible red diode laser. When the laser beam go through the focus lens, the produced heat will gasify the target tissue.

With fractional laser resurfacing the laser beam is broken up or fractionated into many small micro beams which are separated so that when they strike the skin surface small areas of the skin between the beams are not hit by the laser and left intact. These small areas promote a much more rapid recovery and healing with less risk of complications. The micro treatment zones cause sufficient laser injury to promote new collagen production.